Welcome to the Nachmani lab

Differentiation and acquisition of cell identity are fundamental processes in multi-cellular organisms. In the Nachmani lab we investigate translation-based mechanisms that determine cellular identity. Specifically, we focus on ribosomal (r)RNA modifications as regulators of ribosome function and of cell-type-specific translation. We explore the importance of cell-type-specific translation in the physiological settings of normal hematopoiesis, leukemia, and viral infection.

We utilize state-of-the-art molecular tools such as ribosome profiling, RNA modification sequencing and CRISPR-based screens. We combine these with ex-vivo stem cell research and in-vivo models by bone marrow transplantation, genetic mouse models and leukemia xenograft to demonstrate the relevance of these mechanisms to human disease. 

For more details about (some) of our on-going projects check “Research“.