2023

A Bloody Feast - Nutritional Regulation of Hematopoiesis

Ussishkin N and Nachmani D. Journal of Experimental Hematology. 2023. doi: 10.1016/j.exphem.2023.08.004. Epub PMID: 37582454 

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Small Nucleolar (Sno)RNA: Therapy Lays in Translation

Rabany O and Nachmani D. Noncoding RNA. 2023. doi: 10.3390/ncrna9030035. PMID: 37368335 

2019

Germline NPM1 mutations lead to altered rRNA 2'-O-methylation and cause dyskeratosis congenita.

Nachmani D, Bothmer AH, Grisendi S, Mele A, Bothmer D, Lee JD, Monteleone E, Cheng K, Zhang Y, Bester AC, Guzzetti A, Mitchell CA, Mendez LM, Pozdnyakova O, Sportoletti P, Martelli MP, Vulliamy TJ, Safra M, Schwartz S, Luzzatto L, Bluteau O, Soulier J, Darnell RB, Falini B, Dokal I, Ito K, Clohessy JG, Pandolfi PP.

Nat Genet. 2019. doi: 10.1038/s41588-019-0502-z. PMID: 31570891 

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Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program.

Janin M, Ortiz-Barahona V, de Moura MC, Martínez-Cardús A, Llinàs-Arias P, Soler M, Nachmani D, Pelletier J, Schumann U, Calleja-Cervantes ME, Moran S, Guil S, Bueno-Costa A, Piñeyro D, Perez-Salvia M, Rosselló-Tortella M, Piqué L, Bech-Serra JJ, De La Torre C, Vidal A, Martínez-Iniesta M, Martín-Tejera JF, Villanueva A, Arias A, Cuartas I, Aransay AM, La Madrid AM, Carcaboso AM, Santa-Maria V, Mora J, Fernandez AF, Fraga MF, Aldecoa I, Pedrosa L, Graus F, Vidal N, Martínez-Soler F, Tortosa A, Carrato C, Balañá C, Boudreau MW, Hergenrother PJ, Kötter P, Entian KD, Hench J, Frank S, Mansouri S, Zadeh G, Dans PD, Orozco M, Thomas G, Blanco S, Seoane J, Preiss T, Pandolfi PP, Esteller M.Acta Neuropathol. 2019. doi: 10.1007/s00401-019-02062-4. PMID: 31428936

2018

An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance.

Bester AC, Lee JD, Chavez A, Lee YR, Nachmani D, Vora S, Victor J, Sauvageau M, Monteleone E, Rinn JL, Provero P, Church GM, Clohessy JG, Pandolfi PP. Cell. 2018 Apr 19;173(3):649-664.e20. doi: 10.1016/j.cell.2018.03.052. PMID: 29677511 

2017

Vigilin Regulates the Expression of the Stress-Induced Ligand MICB by Interacting with Its 5' Untranslated Region.

Berhani O, Nachmani D, Yamin R, Schmiedel D, Bar-On Y, Mandelboim O. J Immunol. 2017 doi: 10.4049/jimmunol.1601589. PMID: 28356383

2016

HNRNPR Regulates the Expression of Classical and Nonclassical MHC Class I Proteins.

Reches A, Nachmani D, Berhani O, Duev-Cohen A, Shreibman D, Ophir Y, Seliger B, Mandelboim O. J Immunol. 2016. doi: 10.4049/jimmunol.1501550. PMID: 27194785

2015

TSPYL2 is an essential component of the REST/NRSF transcriptional complex for TGFβ signaling activation.

Epping MT, Lunardi A, Nachmani D, Castillo-Martin M, Thin TH, Cordon-Cardo C, Pandolfi PP. Cell Death Differ. 2015. doi: 10.1038/cdd.2014.226. PMID: 25613376

2014

RNA-binding proteins regulate the expression of the immune activating ligand MICB.

Nachmani D, Gutschner T, Reches A, Diederichs S, Mandelboim O. Nat Commun. 2014.

doi: 10.1038/ncomms5186. PMID: 24924487

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MicroRNA editing facilitates immune elimination of HCMV infected cells.

Nachmani D, Zimmermann A, Oiknine Djian E, Weisblum Y, Livneh Y, Khanh Le VT, Galun E, Horejsi V, Isakov O, Shomron N, Wolf DG, Hengel H, Mandelboim O. PLoS Pathog. 2014. doi: 10.1371/journal.ppat.1003963. eCollection 2014 Feb.PMID: 24586166

2012

MiR-10b downregulates the stress-induced cell surface molecule MICB, a critical ligand for cancer cell recognition by natural killer cells.

Tsukerman P, Stern-Ginossar N, Gur C, Glasner A, Nachmani D, Bauman Y, Yamin R, Vitenshtein A, Stanietsky N, Bar-Mag T, Lankry D, Mandelboim O. Cancer Res. 2012. doi: 10.1158/0008-5472.CAN-11-2671. PMID: 22915757

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MiRNA-mediated control of HLA-G expression and function.

Manaster I, Goldman-Wohl D, Greenfield C, Nachmani D, Tsukerman P, Hamani Y, Yagel S, Mandelboim O. PLoS One. 2012;7(3):e33395. doi: 10.1371/journal.pone.0033395. PMID: 22438923

2011

An identical miRNA of the human JC and BK polyoma viruses targets the stress-induced ligand ULBP3 to escape immune elimination.

Bauman Y, Nachmani D, Vitenshtein A, Tsukerman P, Drayman N, Stern-Ginossar N, Lankry D, Gruda R, Mandelboim O. Cell Host Microbe. 2011. doi: 10.1016/j.chom.2011.01.008. PMID: 21320692

2010

The human cytomegalovirus microRNA miR-UL112 acts synergistically with a cellular microRNA to escape immune elimination.

Nachmani D, Lankry D, Wolf DG, Mandelboim O. Nat Immunol. 2010. doi: 10.1038/ni.1916. PMID: 20694010

2009

Diverse herpesvirus microRNAs target the stress-induced immune ligand MICB to escape recognition by natural killer cells.

Nachmani D, Stern-Ginossar N, Sarid R, Mandelboim O. Cell Host Microbe. 2009. doi: 10.1016/j.chom.2009.03.003. PMID: 19380116